The Panama Canal is one of the marvels of the world, and you can experience it for yourself on a cruise out of LA. Four cruise lines offer cruises through the canal. Most are one-way to Florida. See the full calendar of departures below.
The Panama Canal is 100 years old and was recently expanded, so this is a good time to go see it.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2026 departure: January 8.
16-day Panama Canal cruise on Regent Seven Seas. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2026 departure: January 25.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2026 departure: February 9.
14-day Panama Canal cruise on Cunard Line. One-way from Los Angeles to Miami (Florida). Visit Puerto Quetzal (Guatemala), the Panama Canal, Willemstad (Curacao) and Oranjestad (Aruba).
• 2026 departure: April 5.
19-day Panama Canal cruise on Seabourn. One-way from Los Angeles to Miami (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
• 2026 departure: April 7.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2026 departure: September 20.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2026 departure: September 29.
17-day Panama Canal cruise on Celebrity Cruises. One-way from Los Angeles to Tampa (Florida). Visit Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia), Ocho Rios (Jamaica) and Grand Cayman (Cayman Islands).
• 2026 departure: October 1.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2026 departure: October 4.
16-day Panama Canal cruise on Norwegian Cruise Line. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama City (Panama), the Panama Canal, Cartagena (Colombia) and Ocho Rios (Jamaica).
• 2026 departure: October 7.
16-day Panama Canal cruise on Norwegian Cruise Line. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama City (Panama), the Panama Canal, Cartagena (Colombia) and Falmouth (Jamaica).
• 2026 departure: October 13.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2026 departure: December 3.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2026 departure: December 28.
16-day Panama Canal cruise on Regent Seven Seas. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2027 departure: January 24.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2027 departure: March 2.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2027 departure: April 3.
19-day Panama Canal cruise on Seabourn. One-way from Los Angeles to Miami (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
• 2027 departure: May 11.
18-day Panama Canal cruise on Celebrity Cruises. One-way from Los Angeles to Boston (Massachusetts). Visit Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Turk (Turks & Caicos).
• 2027 departure: September 18.
17-day Panama Canal cruise on Norwegian Cruise Line. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama City (Panama), the Panama Canal, Cartagena (Colombia), Ocho Rios (Jamaica) and Grand Cayman (Cayman Islands).
• 2027 departure: September 30.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Port Canaveral (Florida). Visit Cabo San Lucas (Mexico), Mazatlan (Mexico), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2027 departure: October 10.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2027 departure: October 13.
17-day Panama Canal cruise on Norwegian Cruise Line. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama City (Panama), the Panama Canal, Cartagena (Colombia), Falmouth (Jamaica) and Great Stirrup Cay (Bahamas).
• 2027 departure: October 19.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2027 departure: October 24.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2027 departure: December 29.