The Panama Canal is one of the marvels of the world, and you can experience it for yourself on a cruise out of LA. Four cruise lines offer cruises through the canal. Most are one-way to Florida. See the full calendar of departures below.
The Panama Canal is 100 years old and was recently expanded, so this is a good time to go see it.
15-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: January 7.
16-day Panama Canal cruise on Regent Seven Seas. One-way from Los Angeles to Miami (Florida). Visit Ensenada (Mexico), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: January 8.
15-day Panama Canal cruise on Norwegian Cruise Line. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: January 12.
15-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: February 6.
15-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: April 5.
15-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: May 9.
18-night Panama Canal cruise on Crystal Cruises. One-way from Los Angeles to New York (New York). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia), Grand Cayman (Cayman Islands) and Miami (Florida).
• 2024 departure: August 27.
15-night Panama Canal cruise on Celebrity Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: September 19.
14-night Panama Canal cruise on Royal Caribbean. One-way from Los Angeles to New Orleans (Louisiana). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
• 2024 departure: September 28.
15-day Panama Canal cruise on Carnival Cruise Line. One-way from San Francisco to Galveston (Texas). Visit Cabo San Lucas (Mexico), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
• 2024 departure: October 1.
16-night Panama Canal cruise on Royal Caribbean. One-way from Los Angeles to Tampa (Florida). Visit Cabo San Lucas (Mexico), Mazatlan (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama), Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: October 5.
17-day Panama Canal cruise on Norwegian Cruise Line. One-way from Los Angeles to Tampa (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Manzanillo (Mexico), Puerto Chiapas (Mexico), Acajutla (El Salvador), San Juan del Sur (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: November 7.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2024 departure: November 17.
15-day Panama Canal cruise on Norwegian Cruise Line. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: December 6.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Curacao.
• 2024 departure: December 19.
16-day Panama Canal cruise on Norwegian Cruise Line. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2025 departure: January 5.
16-day Panama Canal cruise on Regent Seven Seas. One-way from Los Angeles to Miami (Florida). Visit Ensenada (Mexico), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Panama City (Panama), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2025 departure: January 8.
16-day Panama Canal cruise on Oceania. One-way from Los Angeles to Miami (Florida). Visit Ensenada (Mexico), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2025 departure: January 24.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: February 21.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: March 25.
19-day Panama Canal cruise on Seabourn. One-way from Los Angeles to Miami (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
• 2025 departure: April 9.
18-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to New York (New York). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: May 17.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: September 15.
16-night Panama Canal cruise on Celebrity Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia), Falmouth (Jamaica) and Grand Cayman (Cayman Islands).
• 2025 departure: September 19.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: September 30.
15-day Panama Canal cruise on Norwegian Cruise Line. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama City (Panama), the Panama Canal and Cartagena (Colombia).
• 2025 departure: October 5.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: October 22.
16-day Panama Canal cruise on Norwegian Cruise Line. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Manzanillo (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama City (Panama), the Panama Canal and Cartagena (Colombia).
• 2025 departure: October 23.
16-day Panama Canal cruise on Princess Cruises. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: October 28.
15-day Panama Canal cruise on Norwegian Cruise Line. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama City (Panama), the Panama Canal and Cartagena (Colombia).
• 2025 departure: December 5.